ABSTRACT
@#AIM: To explore the clinical effect of Tongzhihuoluo Granules combined with compound anisodine on the acquired ophthalmoplegia in the middle-aged and elderly. <p>METHODS:We selected 81 patients(81 eyes)with acquired ophthalmoplegia in the middle-aged and elderly who were diagnosed and treated in our hospital from January 2015 to October 2017. All patients were divided into observation group(<i>n</i>=40)and control group(<i>n</i>=41)by treatment methods. The control group was given subcutaneous injection of compound anisodine 2mL near the superficial temporal artery of the affected side. The observation group was combined with Tongzhihuoluo Granules. The clinical efficacy and diplopia distance were compared between the two groups. The pulsatility index and blood flow velocity of the basilar artery before and after treatment were compared between the two groups. <p>RESULTS: The effective rate of ophthalmoplegia in the observation group was 92%(37/40), which was significantly higher than that in the control group(73%, 30/41; <i>P</i><0.05). The incidence of cure time ≤ 2wk in the observation group was significantly higher than that in the control group(<i>P</i><0.05). The recombination distances after treatment in both groups were significantly shortened(<i>P</i><0.01), and the diplopia distance in the observation group was significantly shorter than that in the control group(<i>P</i><0.01). The pulsation index of both groups were significantly lower after treatment(<i>P</i><0.01), and the blood flow velocity was significantly increased(<i>P</i><0.01), and those of the observation group changed more(<i>P</i><0.01). <p>CONCLUSION: The clinical therapeutic effect of Tongzhihuoluo Granules combined with compound anisodine on the acquired ophthalmoplegia in middle-aged and elderly patients is significantly better than that of compound anisodine, which can effectively improve the blood flow of vertebral-basal artery and has high clinical efficacy.